Alzheimer’s Disease: Study Shows Connection Between Disease and Type 2 Diabetes
Senior author Christopher Buettner at the Icahn School of Medicine at Mt. Sinai Hospital in New York, led a study that showed a connection between Alzheimer’s disease and diabetic insulin-resistance. The study found that in mice with Alzheimer’s, there was reduced insulin-signaling and increased resistance in the hypothalamus of the brain. The hypothalamus is an essential brain component involved in hormonal signaling and regulation of nutrient metabolism in skeletal muscle, the liver, and fat.
Insulin-resistance is the primary mechanism in the development of Type 2 diabetes, in which increased levels of insulin desensitize cellular receptors to decrease uptake of sugar from the blood stream and cause hyperglycemia. The study published in the Alzheimer’s and Dementia journal, was the first to suggest the relationship between the two seemingly unrelated disorders. Furthermore, Buettner and his team rationalized that if insulin-signaling was up-regulated in patients with Alzheimer’s, it would decrease their susceptibility of developing Type 2 diabetes.
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